Planta Med. 2013 Jul;79(11):963-5
Authors: Wölfle U, Haarhaus B, Schempp CM
Ultraviolet radiation induces DNA damage and oxidative stress which can result in skin inflammation, photoaging, and photocarcinogenesis. [F20]The flavonoid luteolin that is present in high amounts in the dyers weld, Reseda luteola, is one of the most potent antioxidative plant metabolites and also has ultraviolet-absorbing properties.The aim of this study was to determine whether tocopherol and ubiquinone add synergistic antioxidative values to luteolin. None of the substances showed cytotoxic effects in concentrations from 0.25 to 4 µg/mL. The photoprotective and antioxidant effect of equivalent concentrations of luteolin, tocopherol, and ubiquinone and their combination in a ratio of 4 : 4 : 1 were studied in solar simulator irradiated human skin fibroblasts. Luteolin had a half-maximal radical scavenging concentration of 2 µg/mL, whereas tocopherol and ubiquinone were only effective at higher concentrations. None of the substances showed a phototoxic effect, and only luteolin had a moderate photoprotective effect at 2 µg/mL. The combination of luteolin, tocopherol, and ubiquinone exerted a synergistic radical scavenging effect already at a concentration of 0.25 µg/mL and a complete photoprotection at 2 µg/mL.In summary, our findings suggest that the potent antioxidant and photoprotective effect of flavonoids like luteolin may be further increased by the addition of low concentrations of other antioxidants such as tocopherol and ubiquinone. –PMID: 23839819 [PubMed – indexed for MEDLINE]
Using things like hawthorn-rosemary or sage which has a good source of Luteolin by fusing this in oil and then add Cq 10 and vitamin E ( fuse in either almond oil or olive oil which has vitamin E in them naturally) and use –the ratio is 4:4:1 4 parts luteolin-4 parts vitamin E and 1 part cq 10
100ml would be 4 ml of luteolin- 4 mil Vitamin E 1 mil of Cq 1o
Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction.
Oncol Rep. 2013 Aug;30(2):763-72
Authors: Sun S, Pan S, Miao A, Ling C, Pang S, Tang J, Chen D, Zhao C
Cancer of the prostate gland is the most common invasive malignancy and the second leading cause of cancer-related death in human males. Many studies have shown that black tea reduces the risk of several types of cancer. We studied the effects of active extracts of black tea and the black tea polyphenols theaflavins (TFs), on the cellular proliferation and mitochondria of the human prostate cancer cell line PC-3. Our studies revealed that Yinghong black tea extracts (YBT), Assam black tea extracts (ABT) and TFs inhibited cell proliferation in a dose-dependent manner. We also showed that TFs, YBT and ABT affected the morphology of PC-3 cells and induced apoptosis or even necrosis in PC-3 cells. In addition, it was observed that the samples significantly caused loss of the mitochondrial membrane potential, release of cytochrome c from the intermembrane space into the cytosol, decrease of the ATP content and activation of caspase-3 compared with the control. Taken together, these findings suggest that black tea could act as an effective anti-proliferative agent in PC-3 cells, and TFs, YBT and ABT induced apoptosis of PC-3 cells through mitochondrial dysfunction.—PMID: 23715786 [PubMed – indexed for MEDLINE]
Recipe—Either extract the black Tea in alcohol ( wine –brandy-cognac-vodka or a clear based rum or ethanol in a clear base) or in water and use the teas throughout the day or the use of the tinctures in 10-30 drop increments
Show of the Month March 29 2o14
Water filter from the sapwood in pine tree branches
REPORT CARD ON PRIMARY PREVENTION Chronic Disease- 1998-2008
Link found between pollutants, certain complications of obesity
Persistent organic pollutants affect the stress hormone cortisol
Pollutants may contribute to illness and becoming overweight
Water filter from the sapwood in pine tree branches
February 26, 2014
Massachusetts Institute of Technology
A false-color electron microscope image showing E. coli bacteria (green) trapped over xylem pit membranes (red and blue) in the sapwood after filtration.-If you’ve run out of drinking water during a lakeside camping trip, there’s a simple solution: Break off a branch from the nearest pine tree, peel away the bark, and slowly pour lake water through the stick. The improvised filter should trap any bacteria, producing fresh, uncontaminated water.—In fact, an MIT team has discovered that this low-tech filtration system can produce up to four liters of drinking water a day — enough to quench the thirst of a typical person. In a paper published this week in the journal PLoS ONE, the researchers demonstrate that a small piece of sapwood can filter out more than 99 percent of the bacteria E. coli from water. They say the size of the pores in sapwood — which contains xylem tissue evolved to transport sap up the length of a tree — also allows water through while blocking most types of bacteria.-Co-author Rohit Karnik, an associate professor of mechanical engineering at MIT, says sapwood is a promising, low-cost, and efficient material for water filtration, particularly for rural communities where more advanced filtration systems are not readily accessible.-“Today’s filtration membranes have nanoscale pores that are not something you can manufacture in a garage very easily,” Karnik says. “The idea here is that we don’t need to fabricate a membrane, because it’s easily available. You can just take a piece of wood and make a filter out of it.”–The paper’s co-authors include Michael Boutilier and Jongho Lee from MIT, Valerie Chambers from Fletcher-Maynard Academy in Cambridge, Mass., and Varsha Venkatesh from Jericho High School in Jericho, N.Y.
Tapping the flow of sap
There are a number of water-purification technologies on the market today, although many come with drawbacks: Systems that rely on chlorine treatment work well at large scales, but are expensive. Boiling water to remove contaminants requires a great deal of fuel to heat the water. Membrane-based filters, while able to remove microbes, are expensive, require a pump, and can become easily clogged.–Sapwood may offer a low-cost, small-scale alternative. The wood is composed of xylem[F21], porous tissue that conducts sap from a tree’s roots to its crown through a system of vessels and pores. Each vessel wall is pockmarked with tiny pores called pit membranes, through which sap can essentially hopscotch, flowing from one vessel to another as it feeds structures along a tree’s length. The pores also limit cavitation, a process by which air bubbles can grow and spread in xylem, eventually killing a tree. The xylem’s tiny pores can trap bubbles, preventing them from spreading in the wood.–“Plants have had to figure out how to filter out bubbles but allow easy flow of sap,” Karnik observes. “It’s the same problem with water filtration where we want to filter out microbes but maintain a high flow rate. So it’s a nice coincidence that the problems are similar.”
To study sapwood’s water-filtering potential, the researchers collected branches of white pine and stripped off the outer bark. They cut small sections of sapwood measuring about an inch long and half an inch wide, and mounted each in plastic tubing, sealed with epoxy and secured with clamps.–Before experimenting with contaminated water, the group used water mixed with red ink particles ranging from 70 to 500 nanometers in size. After all the liquid passed through, the researchers sliced the sapwood in half lengthwise, and observed that much of the red dye was contained within the very top layers of the wood, while the filtrate, or filtered water, was clear. This experiment showed that sapwood is naturally able to filter out particles bigger than about 70 nanometers.–However, in another experiment, the team found that sapwood was unable to separate out 20-nanometer particles from water, suggesting that there is a limit to the size of particles coniferous sapwood can filter.
Picking the right plant
Finally, the team flowed inactivated, E. coli-contaminated water through the wood filter. When they examined the xylem under a fluorescent microscope, they saw that bacteria had accumulated around pit membranes in the first few millimeters of the wood. Counting the bacterial cells in the filtered water, the researchers found that the sapwood was able to filter out more than 99 percent of E. coli from water.–Karnik says sapwood likely can filter most types of bacteria, the smallest of which measure about 200 nanometers. However, the filter probably cannot trap most viruses, which are much smaller in size.–Karnik says his group now plans to evaluate the filtering potential of other types of sapwood. In general, flowering trees have smaller pores than coniferous trees, suggesting that they may be able to filter out even smaller particles. However, vessels in flowering trees tend to be much longer, which may be less practical for designing a compact water filter.–Designers interested in using sapwood as a filtering material will also have to find ways to keep the wood damp, or to dry it while retaining the xylem function. In other experiments with dried sapwood, Karnik found that water either did not flow through well, or flowed through cracks, but did not filter out contaminants.–“There’s huge variation between plants,” Karnik says. “There could be much better plants out there that are suitable for this process. Ideally, a filter would be a thin slice of wood you could use for a few days, then throw it away and replace at almost no cost. It’s orders of magnitude cheaper than the high-end membranes on the market today.”——-This research was supported by the James H. Ferry Jr. Fund for Innovation in Research Education.–Story Source-The above story is based on materials provided by Massachusetts Institute of Technology. The original article was written by Jennifer Chu. Note: Materials may be edited for content and length.–Journal Reference-Michael S. H. Boutilier, Jongho Lee, Valerie Chambers, Varsha Venkatesh, Rohit Karnik. Water Filtration Using Plant Xylem. PLoS ONE, 2014; 9 (2): e89934 DOI: 10.1371/journal.pone.0089934
REPORT CARD ON PRIMARY PREVENTION, 1998-2008
AGE ZERO CD (%)* FOUR + CD (%)*
1998 2008 1998 2008
ALL ≥ 65 13.1 7.8 11.6 17.4
ALL ≥ 65 MALE 13.6 8.9 11.3 17.5
ALL ≥ 65 FEMALE 12.8 6.9 11.7 17.3
RANGE 65-69 17.0 11.7 9.1 12.7
RANGE 70-74 14.8 7.5 9.8 16.8
*CD—Chronic diseases. Source: Hung, W. et al. BMC Geriatrics. 2011;11:1-12
From this report card, it is clear that the percentage of the population in the US free of chronic disease decreased dramatically, i.e. the prevalence of chronic disease increased dramatically, and this was independent of gender and was seen in the total ≥ 65 population as well as in two age groups which represent the traditional initial retirement years and the following half-decade leading up to approximately life expectancy. This continues a trend seen in the 1990s and, if this trend were to continue, it eventually will be hard to find anyone over 65 who does not have a chronic disease. And omitted in this study are mental diseases. The World Health Organization is predicting a 70% increase in cancer over the next 20 years. The elderly having four or more chronic diseases by 2008 was approaching 20% prevalence. This is perhaps the most shocking observation. The data in this table represent bad news for those concerned with healthcare costs, but more importantly, for those who view healthy aging as an important goal. Furthermore, it can be argued that the data cannot be dismissedby citing increased efficiency of diagnoses. Mainstream preventive medicine appears to have failed. We are on our own. The study from which the above table was derived also looked at impairment, including impaired cognition, vision, hearing, mobility, urinary continence and the presence of disabilities which impacted daily living. The good news is that the prevalence of impairment International Health News March 2014 Page 2 and disability did not increase in the decade examined, although because of the increase in the number of individuals in the ≥ 65 age group, the absolute numbers increased. Thus not surprisingly, modern medicine appears better at dealing with some of the problems which arise after one has a chronic disease of aging than preventing these diseases in the first place, although earlier diagnosis may be a factor due to some with less severe disease. The authors of the study from which the above data was derived also comment that the main goal of successful aging is the maintenance of independence and they emphasize the stability of the prevalence of impairment and disability. However, it can be argued that the primary goal should be to prevent the disorder in the first place, or arresting or reversing progression.
Detoxification has become a very hot topic in the popular health literature. There are books about detoxification diets, juice fasting for detoxification, detoxification and longevity, liver detoxification, etc, etc. Since concern for toxic overload is
unfortunately justified, it is of interest to attempt to separate mythology from
approaches to detoxification associated with at least some more or less scientific
evidence of human efficacy. The need for human studies is based on the fact that animals in general have different physiological and biochemical mechanisms for eliminating acquired toxic substances and animal studies are only partly transferable. This is unfortunate since the type of experiments routinely performed on animals cannot be carried out with humans for obvious reasons. This review relies heavily on the pioneering and ongoing research and publications of Dr. Stephen J. Genuis and his colleagues at the University of Alberta.
TOXINS AND CHRONIC ILLNESS
What are the determinants of the occurrence of adult chronic illness? The
consensus appears to be infectious agents, genetics, psychological factors,
nutrient deficiencies and toxins. Among these, according to the conventional wisdom, genetics appears to be the most important. It is called the genetic predestination paradigm, the short form of which implies the misfortune of having the wrong parents.1 However the paradigm is challenged by the following: (a) Identical twin studies are not consistent with the paradigm; (b) ancestry frequently is a poor predictor of risks; (c) genomes have not significantly changed over eons but some disorders have escalated dramatically over periods extremely short by comparison; (d) migration and adoption of new lifestyles can profoundly change disease incidence. In fact, it has been estimated that 70% to 90% of disease risks are instead probably due to environmental issues.2—Genetic predisposition to disease has been well established. However, directly and permanently modifying genes does not appear to be the answer and thus the predisposition to specific diseases appears immutable. However, environmental factors interact with an individual’s genome and can cause illness.1 These are called epigenetic influences.[F22] Included are toxic chemicals, viral and fungal exposure and radiation, which are external and internal agents generated for example by a toxic excess of biochemicals associated with inflammation and metabolism and toxins associated with psychological stress. However, epigenetic actions represent only one of many ways that toxins adversely interact with human biochemistry and microbiology. The huge variety of toxins assures a significant variety of mechanisms. If one also considers deficiencies in biochemicals required for humans to thrive, then the combination of toxins and these deficiencies represent together the environmental component of the etiology of illness.1 In practice, mainstream medicine tends to ignore both. The belief that humans, if not undernourished, get everything by way of essential nutrients from their diet has the status of dogma. With external toxins, there is general agreement regarding heavy metals. For externally derived toxins, there is inadequate information regarding thresholds for toxicity since human studies are impossible, animal studies in general not definitive, knowledge of accumulation and locations of storage is lacking and it is not possible to adequately measure distributed body stores. Furthermore, clinical
manifestations may require years to develop. The fetus gets its toxins from the mother through the common blood circulation. Studies of cord blood typically reveal significant levels. The newborn is particularly sensitive to toxins
which can adversely impact critical aspects of the development process all the way throughto adulthood, especially with regard to the brain. This is called the silent epidemic and is the subject of a frightening study from Harvard just published in journal Lancet Neurology.3 With
the fetus or newborn there is obviously an incredibly complex developmental process involved and it is exquisitely sensitive to toxic interference. Consider four common toxins, mercury, lead, glyphosate (in Roundup) and the much publicized bisphenol A. All have atomic weights or molecular weights around 200 g. A rough approximation for the number of cells in the newborn child is a bit less than 1012,, i.e. a thousand billion.4. Using Avogadro’s number, it is easy to calculate the amount required of any one of these toxins in order to have enough for one toxic atom or molecule for every cell in the newborn child’s body. The number
is about 0.3 ng, a third of a billionth of a gram. However, toxins are not evenly distributed and this fraction of a nanogram would in fact concentrate such that some cell contained considerably more, some less or zero. If the toxin accumulates with each exposure, then the
toxic load constantly increases. Thus much smaller amounts are potentially dangerous. The brain’s development is uniquely sensitive to toxic chemicals. The theme of a recent book by Professor Philippe Grandjean (University of Southern Denmark and Harvard School of Public Health) is that the developing brain has only one chance to get it right, and how environmental pollution impairs normal brain developmet.5 It is remarkable that women living in the modern, developed, chemical-saturated world can even give birth to normal babies who will then go on to develop normally. In fact, abnormalities at birth or miscarriage are not uncommon. Child mortality in the US is higher than in most developed countries. The mother probably exhibits no clinical symptoms associated with her toxic burden. The problem of maternal toxins appears to be getting worse.5 However, toxins measured in the mother and in the cord blood provide a starting point for epidemiological studies involving follow-up of newborns which eventually will yield important information. At present, the only solution appears to be either avoidance of exposure before and during pregnancy and while nursing, which is very difficult if not impossible, or detoxification prior to conception, which is almost entirely off the radar of modern medicine. Ignoring or denying environmental toxins is common. The argument that there is no “scientific” evidence of risk at current exposure levels is in fact the traditional approach proven effective years ago by the tobacco industry. For example, many would agree that chemicals that mimic hormones are potentially bad, but maintain that the threshold of risk is above normal exposure, when in fact in many cases the threshold is unknown. When animal studies raise red flags, the response may be that the results are flawed or not transferable, even if normalized to body mass. But animal studies are routinely used by industry to establish “safe” human limits. In the absence of definitive evidence based on human studies, it appears that the zero tolerance is the correct attitude. But with 80,000 chemicals out there, the number of potential toxins is too great, and therefore one must assume that one has an unavoidable toxic burden, the only question being what and how much. Thus the importance of detoxification not specific to any one toxin.
THE TOXIC ZOO
The following is a general account of substances implicated as toxins. The importance and pathophysiology have been reviewed.6 • Naturally occurring organic substances. These include moulds and their metabolites and allergy-causing substance of plant and animal origin. • Inorganic or elemental toxins. Included are the heavy metals arsenic, cadmium, lead, and mercury. Found in dust, drinking water, foods, dental amalgams, and consumer products. Some react strongly with sulphur containing proteins and inhibit enzyme controlled reactions. Heavy metals accumulate in the brain, liver, kidney and bone.
• Pesticides. These are intentionally distributed into the environment because they are toxic and act as insecticides, herbicides and fungicides. Yearly use is measured in tons. Human toxicity has been linked to neurological, endocrine, developmental, reproductive, respiratory and immunological disorders as well as cancer.7 • Persistent organic molecular pollutants. These include chemicals used as flame retardants, stain repellents, anti-wrinkle and non-stick chemicals, fragrances, chemicals added during food preparation, cleaning and cosmetic agents, etc., etc. Also, toxins leached from or released by plastics. Bisphenol-A, a so-called xenoestrogen, is the poster child of this class. Other chemicals include phthalates, stabilizers and dyes. This list includes many synthetic chemicals to which humans have been exposed in only recently evolutionary history. Food borne pollutants increase in concentration as one goes up the food chain and by accumulation in organs and fatty tissue, form a pool of toxic substances in humans with many adverse health effects. Therefore one cannot assume human natural detoxification mechanisms that evolved over eons will be able to deal with this onslaught, a problem which intensified in a post-WWII chemical revolution with synthetic substances designed to enhance taste, flavour, efficiency, convenience, beauty, comfort and so it was claimed, safety. Today both naturally occurring and synthetic toxic substances are ubiquitous in the environment and in humans and unfortunately appear to be a significant cause of illness.1,6 The manufacturers strongly dispute this suggestion, inevitably citing no absolute proof or evidence, a powerful approach which seems to work with at least some governments and regulatory agencies.When these toxic chemicals accumulate in the body, they can reside in a number of locations and thus blood levels or urine levels or hair analysis fail to provide an accurate or even in some cases informative picture of the body burden. Inability to establish individual body burdens impacts not only toxicological studies but also attempts to determine the success of detoxification protocols.
AVOIDANCE OF TOXINS
This obviously should have high priority but the devil is in the details. Sources of most toxic exposure are suggested in the above list of toxins. Thus it appears advisable to consider drinking and cooking with only reverse osmosis water, to regard tap water as suitable for washing and toilets, and shower heads should have carbon filters. Attempts to achieve a chemical-free home are obviously important. Attention is directed to cosmetics and personal care items, cleaning and laundry chemicals, fabrics, carpets and other materials containing fire retardants and/or stain resistant chemicals, and weed and pest control substances. Highly efficient air filters may be important for air pollutants including moulds and small particulate matter. Avoiding frequent consumption of foods known to commonly contain toxins can reduce the body toxic burden. This includes not only some species of fish but also commercial canned food. The problem here is that the levels of toxins in food are highly variable and largely unknown, nor are official safe limits credible. In addition, some suggestions are simply not practical such as living only in older houses to avoid the outgassing of building materials including insulation and particle board as well as new carpets and drapes. It is important to buy rugs, carpets, drapes and mattresses with great care because of toxic organic substances which these items emit, especially fire retardants. A independent lab had recently set up state-of-the-art laboratory for testing levels of toxin in foods, beverages, personal care products and supplements. The initial reports are shocking. From the laboratory, had reported a general conclusion from the analysis of over 1000 foods, supplements, junk foods and popular beverages for heavy metals and other toxins. The conclusion was that unless something is done about this problem, we are doomed. [F23]
The variety of toxins potentially present requiring elimination is so large that it should be evident there is no single detoxification protocol that is comprehensive. However, the problem is even greater since there is very little research on detoxification protocols, and the compartmentalization of toxins in the body further complicates the issue. Some detoxification protocols have been studied only in the context of individuals with very high toxic loads or frank poisoning. Drops in blood or urine levels may conceal large unaffected body stores.–Hair analysis offers problems in interpretation. In what follows, the detoxification protocols that have received some scientific study will be discussed, and as well those without convincing evidence will be listed. The first step in detoxification is to attempt to optimize the body’s own mechanisms. In an important review of detoxification, Sears and Genuis list the following dietary and supplemental intervention for which there is some evidence:7
• Glutathione and sulphur-containing foods such as eggs, fermented cabbage, [F24]onions and garlic are important. Supplementing with N-acetyl cysteine, selenium, taurine and/or methylsulfonylmethane (MSM) can support glutathione and metallothionein synthesis. • Folate may assist arsenic metabolism and elimination. • Alpha-lipoic acid or R-lipoic acid may assist in the detoxification of compounds resulting from mould exposure.
• Adequate calcium and zinc can reduce the absorption of heavy metals.
• Chlorella has been found to decrease absorption and increase excretion of toxicants. Evidence is for mercury, cadmium and dioxin.
• Pectin will reduce absorption and increase elimination
• Some evidence exists for the benefit of restoration of normal flora in the gut with probiotics in order to facilitate removal of toxins from the GI tract.8
Taurine decreases oxidative stress markers resulting from heavy metal exposure. Alpha lipoic acid regenerates reduced glutathione which is an important endogenous defence against heavy metals. N-acetyl cysteine is a chelator of toxic elements and may stimulate glutathione synthesis, especially in the presence of vitamins C and E. Glutathione itself is not generally recommended as supplement since it is destroyed by digestion. However, there are novel delivery systems such as liposomes under development and one formulation is now available over-the-counter. Selenium is important in the context of detoxification. Selenium incorporated in an organic molecule is the indicated form and has been shown to increase mercury secretion and decrease stress-related biomarkers. Supplements not mentioned by Genuis and Sears include milk thistle, curcumin and green tea extract.
Link found between pollutants, certain complications of obesity
February 27, 2014
Institut de recherches cliniques de Montreal
A team of researchers at the IRCM in Montréal led by Rémi Rabasa-Lhoret, in collaboration with Jérôme Ruzzinfrom the University of Bergen in Norway, found a link between a type of pollutants and certain metabolic complications of obesity. Their breakthrough, published online this week by The Journal of Clinical Endocrinology & Metabolism, could eventually help improve the prevention, diagnosis, and treatment of cardiometabolic risk associated with obesity, such as diabetes, hypertension and cardiovascular disease.–Although obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals, termed “metabolically healthy but obese,” appears relatively protected from the development of such cardiometabolic complications. IRCM researchers are studying the factors that seem to protect obese individuals who remain metabolically healthy, in an attempt to find therapeutic avenues to prevent complications for others who are at risk.–“Recently, persistent organic pollutants (POPs) have been found to accelerate the development of prediabetes and obesity in mice, thereby mimicking the unfavourable cardiometabolic profile characteristic of certain obese individuals,” says Rémi Rabasa-Lhoret, MD, PhD, endocrinologist and Director of the Metabolic Diseases research unit at the IRCM. “As a result, the aim of our study was to test whether metabolically healthy but obese individuals have lower circulating levels of POPs than obese individuals with cardiometabolic complications.”–Persistent organic pollutants are human-made chemicals used in agricultural, industrial and manufacturing processes. Due to their toxicity, POPs have been strictly and internationally regulated to ensure public health. However, because they have the ability to resist environmental degradation, POPs can still be found all around the world, even in areas where they have never been used, and remain omnipresent in our environment and food products. Thus, virtually all humans are exposed to POPs daily.–“Exposure to POPs comes primarily from the environment and the consumption of food such as fatty fish, meat and milk products,” explains Jérôme Ruzzin, PhD, expert in the field of research on POPs. “One important characteristic of POPs is their lipid solubility, meaning they accumulate in the body’s fatty tissues. As their name suggests, they are also persistent so the body cannot easily eliminate them. POPs can therefore have significant impacts on human health, and have been shown to affect reproduction, promote cancer, and be involved in the development of metabolic diseases.”–IRCM researchers conducted a study of 76 obese women of similar age, body mass index and fat mass index, in which they analyzed the concentration of 21 POPs, as well as cardiometabolic risk factors. Among 18 detectable pollutants, the women with cardiometabolic complications had higher concentrations of 12 POPs.–“Remarkably, close to 70 per cent of the detectable POPs were significantly higher in individuals with cardiometabolic complications compared to metabolically healthy but obese subjects,” adds Marie-Soleil Gauthier, PhD, co-first author of the study and research associate at the IRCM. “Our study confirms that the two groups have distinct POP profiles, and that metabolically healthy but obese individuals have significantly lower circulating levels of various classes of POPs than patients with complications. A better understanding of the role of POPs could lead to new directions for the prevention, diagnosis, and treatment of cardiometabolic risk associated with obesity.”–“Although this study does not show a causal link, it suggests that pollutants found abundantly in our environment could promote the development of cardiometabolic diseases like diabetes,” concludes Dr. Rabasa-Lhoret. “If future studies confirm this increased risk, such observations could have a significant impact on public health decisions because we will need to dramatically reduce our exposure to these pollutants.”
The abstract to the report can be found at: http://press.endocrine.org/doi/abs/10.1210/jc.2013-3935
Story Source-The above story is based on materials provided by Institut de recherches cliniques de Montreal. Note: Materials may be edited for content and length.–Journal Reference-Marie-Soleil Gauthier, Rémi Rabasa-Lhoret, Denis Prud’homme, Antony D. Karelis, Dawei Geng, Bert Van Bavel, and Jérôme Ruzzin. The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. The Journal of Clinical Endocrinology & Metabolism, February 2014
Persistent organic pollutants affect the stress hormone cortisol
December 28, 2010
Norwegian School of Veterinary Science
Cross section of an adrenal gland from a sheep foetus. Exposure to PCB through foetal life caused changes in adrenal cortex thickness and its ability to produce the stress hormone cortisol. Karin E Zimmer’s PhD research shows that persistent organic pollutants (POPs), such as PCB and mixtures of different POPs, affect the way the adrenal cortex functions and thereby the synthesis of the stress hormone cortisol. Cortisol plays an important role in normal foetal development and, later in life, in retaining normal body functions during periods of stress. Less research has been carried out on the effects of POPs on cortisol levels than on sex hormones.
POPs are widespread in nature and all animals and humans are exposed to them daily, mainly through food. There have been great concerns regarding the potential ability of these pollutants to affect the body’s hormone balance. Zimmer’s thesis sheds light on how exposure during early life stages interferes with hormone levels and may therefore cause harm to health later in life. Zimmer also investigated how the production of hormones such as cortisol and sex hormones were affected by environmental mixtures of POPs extracted from fish. —The thesis reveals that exposure to PCBs during foetal life and the suckling period caused altered cortisol levels in the blood of both foetuses and adult animals. This indicates that exposure during these sensitive, initial stages of life may have long-term consequences. Her findings are important because altered cortisol balance during early life may lead to a predisposition to develop several diseases in adulthood, such as diabetes and cardiovascular diseases.–Knowledge about how POPs work and how different POPs act together is important for the assessment of human health risks. Zimmer used human hormone-producing cells in her study. High levels of brominated flame retardants in a POP mixture extracted from fish in Lake Mjøsa in Norway did not make this mixture more potent as regards increasing hormone synthesis than a similar fish mixture from another lake with considerably lower levels.[F32] Another POP mixture extracted from crude, unprocessed cod liver also had a pronounced affect on the synthesis of cortisol and sex hormones, whereas a mixture from processed, commercial cod liver oil, which is frequently consumed as a dietary supplement, was shown to have only limited effects.[F33]–Karin Zimmer concludes that cortisol synthesis appears to be a sensitive target for POPs and that efforts should be made to find out to what degree this may threaten human and animal health.–Karin Zimmer Cand.med.vet. defended her thesis entitled “Persistent organic pollutants as endocrine disruptors: effects on adrenal development and steroidogenesis” at The Norwegian School of Veterinary Science on 2nd December 2010.–Story Source-The above story is based on materials provided by Norwegian School of Veterinary Science. Note: Materials may be edited for content and length.
Pollutants may contribute to illness and becoming overweight
June 26, 2012
The Research Council of Norway
Lack of physical activity and poor diet alone cannot explain the dramatic rise in obesity and diabetes occurring in many countries, believe some researchers. It is time to face the possibility that hazardous chemicals may also share part of the blame.
The population of the Western world is increasingly falling prey to metabolic syndrome, which is the name for a group of risk factors — such as overweight and insulin resistance — that occur together and increase the risk for coronary artery disease, stroke, and type-2 diabetes.—What can explain this sharp upsurge in the incidence of metabolic syndrome? Both genetics and environmental factors such as diet and physical exercise play a part, but researchers are still missing some key pieces to the puzzle.–“Many studies now indicate that persistent organic pollutants play a major role,” says Jerome Ruzzin, a post-doctoral researcher at the University of Bergen.
From fatty foods
For several years, Dr Ruzzin has been receiving funding from the Research Council of Norway’s Programme on Environmental Exposures and Health Outcomes (MILPAAHEL) to study the effects of persistent organic pollutants (POPs). He believes these substances have much more of a health impact than most people realize.—“Today’s adults are the first generation to experience serious health problems from these substances. If we do not take this challenge seriously,” he cautions, “there is every reason to be concerned about the coming generations as well.”–POPs enter our bodies when we consume fatty foods such as dairy products, meat, and particularly fatty fish. One of Dr Ruzzin’s research findings on mice is that eating salmon that contains high levels of POPs can lead to insulin resistance, one of the main causes of metabolic syndrome. Popping up everywhere–In two recent scientific articles, Dr Ruzzin has sounded the alarm about the harmful health effects of POPs.–“A great number of studies are now showing that people with high concentrations of POPs in their body are developing metabolic syndrome. We are talking about ordinary people who live in normal environments,” stress Dr Ruzzin, “so this means that we are being exposed to far too high levels of POPs that may have a major impact on our health.”–Typically, dietary changes are prescribed to treat metabolic syndrome. But according to Dr Ruzzin, too little is known about the effects of pollutants in specific foods to make any detailed health recommendations. This is why he believes we should waste no time in launching more studies that examine the combination of pollutants and nutrients in humans.
Dangerous cocktail effect
Studies have shown that POPs, even at concentrations below their danger level individually, can interact with other POPs or hazardous substances to cause serious consequences. This combined “cocktail effect” worries Dr Ruzzin.–“Current threshold values for pollutants are probably too high,” says Dr Ruzzin, “which means that the regulatory framework needs changing. Food producers need to eliminate hazardous substances to a far greater extent than they do at present, and we consumers need more information about the kinds of chemicals we could be ingesting with their food products.”
Danish studies have shown that even small amounts of different chemicals found in everyday products can have a cocktail effect. Malformations of the sex organs are one possible consequence. [F34]Researcher Sofie Christiansen of the Technical University of Denmark is concerned.–“There is no doubt that the importance of interactions between different hormone-disrupting chemicals has been underestimated,” she asserted in connection with a conference on environmentally hazardous substances co-hosted by the Research Council and the Norwegian Climate and Pollution Agency this January.–Story Source-The above story is based on materials provided by The Research Council of Norway. Note: Materials may be edited for content and length.
[F1]Per Os = orally
[F2]Interesting play on words on how this is being used to explore military use in space
[F3]May have to RE Evaluate cause due to aluminum particulates and barium and radioactive particles and nano polymers falling from the sky—this can be an issue and the real cause of this condition happening
[F4]Almost sounds like a Marketing Game—there is some truth to the genetic acceptance but this would be contingent to the genes in the foods rather then the individual –in some cases there maybe an element to this where there maybe a mutated gene in a person causing some kind of anomaly –but the real test should be the test in the genetics of food
[F5]We are dealing with worms who would have a direct contact to genetics
[F6]May have to RE Evaluate cause due to aluminum particulates and barium and radioactive particles and nano polymers falling from the sky—this can be an issue and the real cause of this condition happening
[F7]This is an Illuminati doctrine and when humans and Nature can not co exist human are to be expendable—go asked the natives you can see how this is manifesting in North America
[F8]Now You have to Wonder was this a Self Induced entitlement—with all the wonderful science on this tech we all know there is nothing sustainable here about it
[F9]There are 3 seed banks which have stored non GMO seeds —these are usually released after a cataclysmic event to re start the food supply again
[F10]Never Mind Just America —the whole planet—there has been an ongoing insanity to feed animals GMO based foods—to avoid a controversy with having it grown direct—they just allowed the soil to be contaminated with these genetics and now the worms –bugs- bacteria –fungi will all be affected by this
[F11]This is a JOKE and do not waste your time the USDA is assisting in the implementation of the Monsanto and Biotech properties
[F12]Counterfeits will be of no value
[F13]Due to the condition of a person in recovery stage this would be the easiest way to issue health and vitality back without exerting a high amount of energy and resources the body would need to use —
[F14]To protect against quacks—hmm seems like parliament has failed the quackery we are dealing with today is coming from the gov’t instituted systems and the medical and pharmaceutical and medical supply places —so much for this “legal “ protection
[F15]A coordinated attack by gov’t corporocracy that dismantled this activity before it got off he ground
These people who were chased away by fear should be ashamed of themselves –and should have resisted instead—they gave in to nothing
[F16]In 1984 the USA and Canada Gentically Engineered Mosquitos and released them along the St Lawrence Sea way and in Punta Florida—shortly people were having Fibro and Restless Leg issue
[F17]More like a Double agent even on some sites where they are reporting sensationalism they are basically disinfoing what is going on
[F18]Which was the excuse of these disinformants –that the type of flame that was used was contaminating the results —when in fact it had nothing to do with the results—anyone who Is 50 or older knows when you light a match or any flame to real snow irregardless of location it melts into water
[F19]A Loophole to enact a Biowarfare like attack or in this case the GE insects that can spread the disease
[F20]May have to RE Evaluate cause due to aluminum particulates and barium and radioactive particles and nano polymers falling from the sky—this can be an issue and the real cause of this condition happening
[F21]a compound tissue in vascular plants that helps provide support and that conducts water and nutrients upward from the roots, consisting of tracheids, vessels, parenchyma cells, and woody fibers.
in botany, part of the vascular system that conveys water and dissolved minerals from the roots to the rest of the plant and may also furnish mechanical support. Xylem consists of specialized water-conducting tissues made up mostly of narrow, elongated, hollow cells. These cells may be of several types, including tracheids (the basic cell type), vessel members, fibres, and parenchyma. Xylem constitutes the major part of a mature woody stem or root; the wood of a tree is composed of xylem
[F22]Chemtrails-Smart Meters – ELF’s-GMO’s-GE-Vaccinations-_Flouride-Chlorine( in excess) MetalloEstrogens-Pesticides-Glyphosates-Frequencies-Nanoparticles—all of these wil have an epigenetic effect on your DNA and Genetic code
[F23]Your only doomed if you rely on the current system and allow yourself to be in a comfort zone without the awareness of what is out there —even in the supposed safe GRAS and USDA and Organic —you cannot allow your self the comfort of trust to these institutions since they can be paid off to look elsewhere and avoid dealing with a contaminant or poison or eve refute studies indicating the dangers of GE or GMO or Chemically laden or Colour loaded food supplies
[F24]Utilize STS as well with Ascorbic Acid
[F25]This is an Illuminati doctrine and when humans and Nature can not co exist human are to be expendable—go asked the natives you can see how this is manifesting in North America
[F26]Now You have to Wonder was this a Self Induced entitlement—with all the wonderful science on this tech we all know there is nothing sustainable here about it
[F27]There are 3 seed banks which have stored non GMO seeds —these are usually released after a cataclysmic event to re start the food supply again
[F28]Never Mind Just America —the whole planet—there has been an ongoing insanity to feed animals GMO based foods—to avoid a controversy with having it grown direct—they just allowed the soil to be contaminated with these genetics and now the worms –bugs- bacteria –fungi will all be affected by this
[F29]This is a JOKE and do not waste your time the USDA is assisting in the implementation of the Monsanto and Biotech properties
[F30]Almost sounds like a Marketing Game—there is some truth to the genetic acceptance but this would be contingent to the genes in the foods rather then the individual –in some cases there maybe an element to this where there maybe a mutated gene in a person causing some kind of anomaly –but the real test should be the test in the genetics of food
[F31]We are dealing with worms who would have a direct contact to genetics
[F32]In other words the exposure alone was the cause—irrespective of the amounts of exposure
[F33]Again this is worded in such a way to make one have a false sense of security the levels as we have just seen in the previous sentence is showing whether high or low levels is showing lethal effects and this does not justify the fish oils —remember Norway is one of largest fish oil producing countries so the reports may not necessarily complete
[F34]Interesting since the endocrine system is a main target to reduce the population this would stand to reason why so little is going on to properly protect the population