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    Radioprotective Health Supporting foods and Herbs and supplements
    Baking soda (sodium bicarbonate) baths
    If you had an X-rays or radiation treatments for cancer, A radionics practitioner said that you can soak your body in baking soda baths to help pull out the radiation from your body. If you look all over the web, there is talk about patients who have had mouth cancer who were given radiation treatments to get rid of the cancer, and then told to gargle with baking soda mixed in water.”
    Baking soda (sodium bicarbonate) rinses
    “The most effective measure to treat RT-induced mucositis in patients with head and neck cancer is frequent oral rinsing with a sodium bicarbonate rinse, to reduce the amount of oral microbial flora.” (Oncol Nurs Forum. 2002 Aug;29[7]:1063-80. A research review of the current treatments for radiation-induced oral mucositis in patients with head and neck cancer. Shih A, Miaskowski C, Dodd MJ, Stotts NA, MacPhail)
    Baking soda (sodium bicarbonate) plus sea salt baths
    Take 20-minute baking soda/ sea salt baths (mixing half a pound of salt and half a pound of baking soda) to drain the body of DOR (deadly orgone energy as described by Dr. Wilhelm Reich) etc. Since such baths are “energy draining”, she advises to be careful when getting up from them (circulation) and lie naked in the sun afterwards to recharge one’s battery. I would add the salt when the bathtub is somewhat filled already to avoid possible damage to any metal parts.
    Cysteine hydrochloride
    Dr. Donsbach writes: “An amino acid, cysteine protects against the damage of radiation by terminating the free radicals produced by ionizing radiation.” Cysteine, together with methionine, cystine,Alpha Lipoic Acid, Taurine and their derivatives, is numbered among the “sulphurated amino acids” due to the fact that these amino acids contain sulfur in addition to carbon, hydrogen, nitrogen and oxygen. Sulfurated amino acids.
    Radioprotective Herbs: LarreaRx chapparal – Burdock root – Mint extract- Curcumin extract – Tumeric spice – Boswellia extract- Periwinkle- Basil- Celery Root- Dandelion-Milk Thistle
    Post Radiation Drug Therapies- ACE inhibitors for the kidney, lung and CNS)- Growth factors (G-CSF, GM-CSF, KGF, EPO) to treat the–bone marrow, whole body–• Chelating and isotope-competing agents (Prussian Blue, 7–DTPA, EDTA, potassium iodide, penicillamine, alginates) for the thyroid and bone marrow Pentoxifylline, Vitamin E and SOD to treat fibrosis– Antiemetics to target the GI tract and CNS- Pentoxifylline for fibrosis– Amifostine (anticarcinogenic effects) for mutagenesis-carcinogenesis (given within 3 hours of exposure)- Tempol and other nitroxides for the whole body and fibrosis-• Stem cell transplants (bone marrow, umbilical cord blood, peripheral blood, liver, CNS) for the bone marrow, CNS, liver.
    Alkalinizers to Remove Uranium and other Radioisotopes — EO Electrolyzed Water — TriSalts – Ecological Formulas BioAlkalinizer – BioGenesis -Buffered Vitamin C – Ca, Mg, Zn – Ascorbates
    Spirulina reduces the quantity of Radioactive Isotopes absorbed into the body and thereby helps to counteract the toxic effects of exposure to Radioactivity.
    Animal Organ Supplements
    Spleen Extract counteracts the damage to the Immune System caused by exposure to Radioactivity.—
    Herbs and Supplements For Anti-Radiation
    FAloe vera (gel applied topically) counteracts the ability of Radioactivity exposure to cause Radioepithelitis (destruction of the epithelium of the Skin).
    FChaparral protects the body from the toxic effects of Radioactivity.
    FGinkgo biloba protects the body from the damage to Chromosomes associated with exposure to Radioactivity.
    FSarsaparilla protects against the toxic effects of Radioactivity.
    FTea (especially Green Tea) protects the body’s Cells against the damage caused by Radioactivity (due to the Epigallo-Catechin-Gallate (EGCG) content of Green Tea).
    FIodine alleviates Radiation Sickness (specifically the damage to the Thyroid) that occurs as a result of exposure to Radioactivity (Radioactive Iodine-131). The best form of Iodine for protecting against Radiation Sickness after exposure to excessive Radioactivity is Potassium Iodate.
    FEpigallo-Catechin-Gallate (EGCG) protects the body’s Cells against the damage caused by Radioactivity.
    FLuteolin protects the body’s Cells against the damage caused by Radioactivity.
    FZinc (especially Zinc Aspartate consumed orally) reduces the lethality of exposure to Radioactivity (when Zinc is consumed prior to exposure to Radioactivity).
    FLipoic Acid reduces the toxic effects of exposure to Radioactivity: Persons exposed to Radioactivity after the Chernobyl incident (in Russia) who received Lipoic Acid supplements exhibit greatly lowered oxidative damage as a result of Radioactivity exposure.
    FVitamin C improves the ability of the body to resist the toxic effects of exposure to Radioactivity: Guinea pigs that were supplemented with large dosages of Vitamin C combined with Bioflavonoids were able to withstand twice the known lethal dosages of Radioactivity. Vitamin C (10 grams per day) decreases the Bleeding and Cell degeneration that occurs as a result of exposure to Plutonium Radioactivity.— Vitamin E and C reduced radiation-induced mutations and chromosomal damage in mammalian cells, and radiation-induced lethality
    FCysteine protects the body’s Cells from many of the toxic effects of exposure to Radioactivity.
    FFFRadiobiological studies have identified several radioprotective compounds some of which are non-toxic to humans. The identification that sulfhydryl (SH)-compounds are potent radioprotective agents is considered as one the most important discoveries in applied radiobiological research [5]. Unfortunately, most widely studied SH-compounds like cysteamine, cystamine and aminoethylisothiourea dihydrobromide (AET) and a cysteamine analogue, amifostine, were toxic to humans . However, compounds such as N-acetylcysteine (NAC) and alpha-lipoic acid that are rapidly absorbed and elevate intracellular levels of glutathione (perhaps the most ubiquitous endogenous SH-compound in ameliorating sources of oxidative stress), are of radioprotective value and are, within certain dose ranges, non-toxic to humans. Dietary antioxidants such as vitamins E, C and beta-carotene are of radioprotective value, but very little attention has been given to these compounds with respect to their use in protecting normal tissue against radiation damage in humans. It is therefore possible to develop a non-toxic, cost-effective mixture of antioxidants (dietary and glutathione-elevating agents) that can provide biological protection against radiation damage based on several criteria including mutations. Indeed, such radioprotective products have been patented (pending), and are available commercially. In vitro, animal and human studies that support the rationale of these radioprotective products are described below.— Vitamin E and selenium reduced radiation-induced transformation in cell culture; the combination was more effective than the individual agents ..
    FL-Dopa protects the body’s Cells from many of the toxic effects of exposure to Radioactivity.
    FHyaluronic Acid (cream applied topically) counteracts the ability of Radioactivity exposure to cause Radioepithelitis.
    FBeta-Carotene protects against many of the toxic effects of exposure to Radioactivity. — Natural beta-carotene protected against radiation-induced neoplastic transformation in cell culture
    FLycopene protects against many of the toxic effects of exposure to Radioactivity.
    FMelatonin protects the body’s Cells and tissues against the toxic effects of exposure to Radioactivity.
    Evaluation of silymarin as a promising radioprotector.
    Z Naturforsch C. 2010 May-Jun;65(5-6):337-46
    Authors: Adhikari M, Arora R, Chawla R, Sharma J, Dhaker AS, Gupta D, Dubey N, Kumar R, Ivanov V, Gadjeva V, Gevrenova R, Sharma RK
    Silymarin, a purified extract of seeds of Silybum marianum L. and well known for its hepatoprotective abilities, has been evaluated for inherent utility as a radioprotective agent. A fraction (INM-7035) was authenticated by characterizing the percentage composition of silybin A and B (39.9% and 57.4%). Free radical scavenging activities of INM-7035 against superoxide radicals (>68%), hydroxyl radicals (>33.75%), DPPH (67.2%), and ABTS (32.4%) were also evaluated. The fraction chelated (>30%) ferrous ions, thereby able to restrict amplification. INM-7035 exhibited >50% peroxyl radical scavenging activity in the lipid phase along with dose-dependent (R2 = 0.990) reducing power in the aqueous phase. Radiation-induced free radical flux can lead to disruption of biomolecules like membrane lipids. INM-7035 completely inhibited lipid peroxidative stress in case of membranes against supralethal radiation stress in the liposomal system. The ability of INM-7035 to modulate the levels of NF-kappaB, indicated its inherent potential as a radioprotective bioactive constituent.—PMID: 20653235 [PubMed – indexed for MEDLINE]
    Formulations and Recipes
    Ø Recipe Liver and Thyroid and Brain Effect+—combine milk thistle seeds 1 teaspoon with sea weed 2 oz and sage 1 /2 tsp dry 2-3 sprigs fresh and dandelion ( luteolin ) 2 oz of root or leaf- and water 2-3 pints–make a tea with this as a protectant for radiation exposure—liver regenerator—hormone balancer—thyroid regulator—brain protectant—mood stabilizer—adrenal support—blood support—
    Ø Recipe—Using lugols iodine or SSKI or Iodoral supplements at an 80 mg a day in divided small doses will assist the body in the removal of Radiation Poisoning—taking any of these supplements prior to taking a Anti Radiation bath will assist in not only detoxing the rads out but protecting the thyroid against the chlorine in the water
    Ø Recipe—Anti Radiation Bathing —take ½ – 1 cup of baking soda and add ½ – 1 cup of Epsom salt and ½- 1 cup of bleach—mix well in the bath—as hot as you can tolerate this—and sit in minimally for 20 minutes—when arising from the bath Do not rinse or very superficially and allow to let sit on the surface of the skin
    Ø Recipe Bioflavonoid Peel the Citrus fruits like a potato—what you will have is a higher amount of the components of the Bioflavonoid—you can as well use the essential oils of any citrus and spray them on the bioflavonoid and allow to dry—powder this down and sift after drying—and consume in juices — sprinkle on foods ( you can add potassium chloride or potassium iodide with this and apply it to your foods) you can as well before you dry this apply either a lugols solution or a SSKI solution to this to have a added benefit by apply 1-2 drops of the sski or 2-4 drops of the lugols to each slice and then allow to dry and then powder down the and again apply this on your foods—
    Plant Antioxidant May Protect Against Radiation Exposure
    ScienceDaily (Sep. 24, 2008) — Resveratrol, the natural antioxidant commonly found in red wine and many plants, may offer protection against radiation exposure, according to a study by the University of Pittsburgh School of Medicine. When altered with acetyl, resveratrol administered before radiation exposure proved to protect cells from radiation in mouse models. The study, led by Joel Greenberger, M.D., professor and chairman of the Department of Radiation Oncology at the University of Pittsburgh School of Medicine, is overseen by Pitt’s Center for Medical Countermeasures Against Radiation. The center is dedicated to identifying and developing small molecule radiation protectors and mitigators that easily can be accessed and administered in the event of a large-scale radiological or nuclear emergency. “New, small molecules with radioprotective capacity will be required for treatment in case of radiation spills or even as countermeasures against radiological terrorism,” said Dr. Greenberger. “Small molecules which can be easily stored, transported and administered are optimal for this, and so far acetylated resveratrol fits these requirements well.””Currently there are no drugs on the market that protect against or counteract radiation exposure,” he added. “Our goal is to develop treatments for the general population that are effective and non-toxic.”Dr. Greenberger and his team are conducting further studies to determine whether acetylated resveratrol eventually can be translated into clinical use as a radioprotective agent. In 2004, this same team of researchers identified the drug JP4-039, which can be delivered directly to the mitochondria, the energy producing areas of cells. When this occurs, the drug assists the mitochondria in combating radiation-induced cell death. The results of the research were presented during the American Society for Therapeutic Radiology and Oncology’s (ASTRO) 50th Annual Meeting in Boston.The abstract, “Acetylated resveratrol: A new small molecule radioprotector,”was presented at a poster discussion session on Sept. 23. The study was funded by a $10 million grant from the National Institute of Allergy and Infectious Diseases to establish the Center for Medical Countermeasures Against Radiation at the University of Pittsburgh.—Adapted from materials provided by University of Pittsburgh Schools of the Health Sciences, via EurekAlert!, a service of AAAS.
    The antiradiation properties of the ecdysteroid-containing compounds]—
    [Article in Russian]—Shevchenko OG, Zagorskaia NG, Kudiasheva AG, Shishkina LN. Abstract—The antiradiation properties of the ecdysteroid-containing preparations (“serpisten” and inokosterone) are studied under their application before or after the 22.6 cGy chronic low intensity gamma-irradiation of mice. It is shown that the antiradiation of these compounds depend on the dose of preparations and time of the application before or after irradiation of mice. “Serpisten” prevented the decrease of the growth of the body mass of irradiated mice. The normalization of the phospholipid composition of the mice liver and blood erythrocytes for the most investigated parameters revealed under the application of this compound at the dose of 50 mg/kg after the irradiation of animals. The capacity of “serpisten” to decompose of peroxides is shown in vitro. Inokosterone had the certain anabolic properties, caused the normalization of the total peroxidase activity of blood and intensity of the lipid peroxidation (LPO) in brain and in liver, and also the repair of the interrelation between the LPO intensity and catalase activity in the irradiated mice liver. The obtained results allow to conclude that the antiradiation properties of the ecdysteroid-containing preparations under the chronic low intensity irradiation of animals at the low dose due to their capacity to depend on the LPO regulatory system parameters.—PMID: 17953438 [PubMed – indexed for MEDLINE]
    Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow.
    Jagetia GC, Venkatesha VA, Reddy TK.—-Department of Radiobiology, Kasturba Medical College, Manipal 576119, India.
    Free radicals are responsible for the induction of damage to the cellular DNA that leads to the formation of chromosome aberrations. Antioxidants are known to scavenge free radicals, thereby decreasing the degree of such effects. Radiation is a well-known inducer of free radicals and compounds that can scavenge free radicals may reduce radiation-induced DNA damage. Naringin, a bioflavonoid predominant in grapefruit and other citrus fruits, has been found to scavenge free radicals, therefore it may also reduce radiation-induced damage. The aim of the present study was to evaluate the radioprotective action of 2 mg/kg naringin in the bone marrow of mice exposed to different doses of (60)Co gamma-radiation by scoring the frequency of asymmetrical chromosomal aberrations. The irradiation of mice resulted in a dose-dependent elevation in the frequency of aberrant cells, acentric fragments, chromatid and chromosome breaks, dicentrics and exchanges. All these aberrations were elevated with scoring time up to 24 h post-irradiation and declined thereafter, except chromatid breaks, which were maximum at 12 h post-irradiation. Treatment of mice with 2 mg/kg body wt naringin before exposure to various doses of gamma-radiation resulted in a significant reduction in the frequencies of aberrant cells and chromosomal aberrations like acentric fragments, chromatid and chromosome breaks, centric rings, dicentrics and exchanges. The evaluation of free radical scavenging activity of naringin revealed a dose-dependent scavenging of hydroxyl, superoxide and 2,2 equal to or precedes -diphenyl-1-picryl hydrazyl radical. Naringin at 5 microM scavenged the 2,2-azino-bis-3-ethyl benzothiazoline-6-sulphonic acid cation radical very efficiently, where a 90% scavenging was observed. Our study demonstrates that naringin can protect mouse bone marrow cells against radiation-induced chromosomal damage.– PMID: 12840107 [PubMed – indexed for MEDLINE]
    The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study.
    Jagetia GC,Reddy TK.
    Department of Radiobiology, Kasturba Medical College, Manipal 576119, India.
    The effect of various doses, viz. 0, 0.5, 1, 2, 4, 6 and 8 mg/kg body weight of naringin (NIN) (a citrus flavanone) was studied on the alteration in the radiation-induced micronucleated polychromatic (MPCE) and normochromatic (MNCE) erythrocytes in mouse bone marrow exposed to 2 Gy of 60Co gamma-radiation. The treatment of mice with various doses of NIN before exposure to 2 Gy resulted in a significant decline in the frequency of MPCE when compared to the non-drug-treated irradiated control. However, the greatest reduction in MPCE was observed for 2mg/kg body weight NIN, accompanied by a highest PCE/NCE ratio when compared with the non-drug-treated irradiated control. Therefore, further studies were carried out using this dose of NIN, where the animals were administered with 2mg/kg body weight of NIN before exposure to 0, 0.5, 1, 2, 3 and 4 Gy of gamma-radiation. The frequency of MPCE and MNCE increased in a dose-dependent manner in both the non-drug-treated irradiated control and NIN-pretreated irradiated groups up to a dose of 2 Gy, while a further increase in the irradiation dose resulted in a significant decline in MPCE and MNCE frequencies in both groups. Pretreatment of mice with 2mg/kg body weight of NIN resulted in a significant decline in the frequencies of MPCE and MNCE. NIN treatment not only reduced the frequency of MPCE with one micronucleus, but also of MPCE with multiple micronuclei (MN), indicating its ability to reduce complex chromosome aberrations. Conversely, the PCE/NCE ratio declined in a dose-dependent manner in both groups. The treatment of mice with NIN before exposure to different doses of gamma-radiation resulted in the inhibition in this decline in the PCE/NCE ratio. Our study demonstrates that NIN is able to protect mouse bone marrow cells against the radiation-induced DNA damage and decline in the cell proliferation as observed by a reduction in the micronucleus frequency and an increase in PCE/NCE ratio, respectively, in the NIN-pretreated irradiated group. -PMID: 12160890 [PubMed – indexed for MEDLINE]
    Enhancement of antiradiation potential of some aminothiols by beta-carotene.
    Al-Wandawi HK.
    Division of Environmental Researches and Workers Protection, Iraqi Atomic Energy Commission, Baghdad, Iraq.
    In the present study, protection of mice, BALB/c inbred as measured by survival at 30 days against whole-body gamma exposure at two dose levels, namely, 7.60 and 10.12 Gy by prior irradiation treatment with combination of beta-carotene, N-(2-mercapto-propionyl)-glycine (MPG) and S-(2-aminoethyl) isothiouroniumbromide hydrobromide (AET), is reported. It was found that administration of beta-carotene (1 mg per 20 g body mass) and 24 h before whole-body irradiation (7.60 Gy) had significantly improved the post-irradiation survival. It was also found that administration of a combination of AET (260 mg per kg body mass) and MPG (60 mg per kg body mass) 20 min before exposure to 7.60 Gy gamma irradiation to mice which have been treated with beta-carotene (1 mg per 20 g body mass) 24 h before exposure had resulted in 80% survival in comparison to 10% survival recorded for control animals. On the other hand, when the animals were exposed to a higher dose (10.12 Gy) under similar experimental conditions as above, a significant improvement in survival was observed during the first 10 days following the exposure but only a slight effect afterward. On the other hand, the response of male and female mice 10 days after exposure to the above radiation dose indicated that the females were more radioresistant than the males. Copyright 2003 S. Karger AG, Basel— PMID: 12743471 [PubMed – Indexed for MEDLINE]
    Caffeine protects mice against whole-body lethal dose of gamma-irradiation.
    George KC, Hebbar SA, Kale SP, Kesavan PC.
    Biosciences Group, Bhabha Atomic Research Centre, Trombay, Mumbai, India.
    Administration of caffeine (1,3,7-trimethylxanthine), a major component of coffee, to Swiss mice at doses of 80 or 100 mg/kg body weight 60 min prior to whole-body lethal dose of gamma-irradiation (7.5 Gy) resulted in the survival of 70 and 63% of animals, respectively, at the above doses in contrast to absolutely no survivors (LD-100/25 days) in the group exposed to radiation alone. Pre-treatment with a lower concentration of caffeine (50 mg/kg) did not confer any radioprotection. The protection exerted by caffeine (80 mg/kg), however, was reduced from 70 to 50% if administered 30 min prior to irradiation. The trend statistics reveal that a dose of 80 mg/kg administered 60 min before whole-body exposure to 7.5 Gy is optimal for maximal radioprotection. However, caffeine (80 mg/kg) administered within 3 min after irradiation offered no protection. While there is documentation in the literature that caffeine is an antioxidant and radioprotector against the oxic pathway of radiation damage in a wide range of cells and organisms, this is the first report demonstrating unequivocally its potent radioprotective action in terms of survival of lethally whole-body irradiated mice.
    Radioprotective potential of Rosemarinus officinalis against lethal effects of gamma radiation : a preliminary study.
    Jindal A, Soyal D, Sancheti G, Goyal PK.
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur – 302 004, India.
    The radioprotective effect of Rosemarinus officinalis extract (ROE) was studied in mice exposed to 8 Gy of gamma radiation. The optimum dose for radioprotection was determined by administering 100, 200, 400, 800, 1000, 1500, and 2000 mg/kg body weight of ROE orally once daily, consecutively for five days before irradiation. Treatment of mice with ROE, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug-treated irradiated controls. The dose of ROE found to be most effective against radiation was 1000 mg/kg body weight because this dose increased the survival time and reduced the mortality rate of mice significantly. Body weight loss in ROE administered irradiated animals was significantly less in comparison with animals who were given radiation treatment alone. Furthermore, irradiation of animals resulted in an elevation in lipid peroxidation (LPx) and a significant decrease in glutathione (GSH) in blood and liver. Conversely, administration of animals with ROE before irradiation caused a significant decline in LPx accompanied by a significant increase in GSH concentration. The present study demonstrates that Rosemarinus officinalis leave extract is a good radioprotector.— PMID: 17341204 [PubMed – indexed for MEDLINE]
    Radioprotective effects of Aloe vera leaf extract on Swiss albino mice against whole-body gamma irradiation. Goyal PK, Gehlot P.
    Department of Zoology, University of Rajasthan, Jaipur – 302 004, India.
    The skin, being a cell-renewal system, is one of the first organs to be affected in total-body irradiation during radiotherapy. An attempt has been made in the present study to explore radiation-induced biochemical alterations caused by whole-body gamma irradiation and their modulation in Swiss albino mice by Aloe vera leaf extract (AVE). Mice were selected for this study from an inbreed colony and divided into four different groups: I (double-distilled water-treated group): considered as normal; II (Aloe vera-treated group): the animals were administered 1 g/kg body-wt/day Aloe vera leaf extract; III (radiation-treated group): the animals were exposed to 6 Gy gamma radiation at the dose rate of 0.96 Gy/min; and IV (combination group): animals were administered Aloe vera leaf extract continuously for 15 consecutive days, and on the 15th day they were irradiated to 6 Gy gamma radiation after 30 minutes of extract administration. The animals from the above groups were autopsied after 6 hours, 24 hours, and at 3, 7, 14, and 21 days of radiation. Biochemical estimations of DNA, lipid peroxidation, glutathione, catalase, and superoxide-dismutase were made. Total DNA, catalase, superoxide dismutase (SOD) activity in the skin, and glutathione (GSH) in the liver and blood significantly decreased compared to normal, but lipid peroxidation (LPO) in the liver and blood increased in the irradiated control group. In contrast, in experimental animals, DNA, catalase, and SOD in the skin and GSH in the liver and blood increased significantly, whereas LPO in the liver and blood decreased in comparison to irradiated control animals. Thus, Aloe vera leaf extract is found to have damage-resistant properties against radiation-induced biochemical alterations in Swiss albino mice.– PMID: 19392655 [PubMed – indexed for MEDLINE]
    Radioprotective influence of Mentha piperita (Linn) against gamma irradiation in mice: Antioxidant and radical scavenging activity.
    Samarth RM, Panwar M, Kumar M, Kumar A.Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India.
    Retraction in: Int J Radiat Biol. 2007 Nov-Dec;83(11-12):897.
    PURPOSE: To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice. MATERIALS AND METHODS: Animals were given either double distilled water or leaf extract of M. piperita orally (1 g/kg bwt/day) once a day for three consecutive days. Thirty min after the last treatment mice were exposed to 8 Gy of gamma radiation. Mice were autopsied at 30 min post-irradiation. Biochemical parameters were studied to assess the radioprotective effect of leaf extract of M. piperita. RESULTS: Animals pretreated with leaf extract of M. piperita and exposed to 8.0 Gy gamma radiation showed a significant increase in the activities of reduced glutathione content (p < 0.001), glutathione peroxidase (p < 0.005), glutathione reductase (p < 0.001), glutathione S-transferase (p < 0.005), superoxide dismutase (p < 0.005), and catalase (p < 0.005). Irradiated group pretreated with leaf extract of M. piperita showed significant decrease in malondialdehyde (MDA) formation in liver. The leaf extract of M. piperita showed strong radical scavenging activity in both the 1, 1 diphenyl-2-picryl hydrazyl radical (DPPH*) and 2, 2 azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS*+) assays. CONCLUSIONS: The results of the present investigation suggest the antioxidant and free radical scavenging activities of leaf extract of M. piperita are the likely mechanism of radiation protection.